Roundtable Discussion: How Can We Advance GPCR Drug Discovery Through Cell-Based Screening & Structural Biology?

• How can we best balance studying GPCRs in their native cellular environment versus using isolated or recombinant proteins?
• Which protein sourcing and experimental system approaches optimise GPCR stability, activity, and translational relevance?
• What structural biology strategies, including cryo-EM and NMR, are most effective for guiding rational GPCR drug design?

Speakers:

Alexey Rak

Head of Bio Structure & Biophysics

Sanofi