Potent Modulators of GPR126 Promote Schwann Cell-Mediated Myelination of Peripheral Nerve Axons

• Discovering potent GPR126 modulators, including picomolar peptide agonists and low-molecular-weight agonists/PAMs, and using cryo-EM to reveal a novel allosteric binding site
• Demonstrating that agonist and PAM modulation of GPR126 increases axon myelination in a Schwann cell in vitro model via activation of myelination pathways
• Presenting aGPCRs as tractable drug targets, with GPR126 modulation offering a promising route for developing therapeutics for peripheral neuropathies

Speakers:

Paul Groot-Kormelink

Associate Director in Discovery Sciences - Biomedical Research

Novartis