Advancing Functional Assays for GPCRs to Accelerate Hit-to-Lead Discovery & Improve Druggability Assessment

• Strategies to design and implement new approaches for quantifying GPCR signalling, enabling ligand comparison across diverse signalling pathways
• Application of reverse-design principles to functionalize known ligands with fluorophores and tracers for real-time visualization and measurement of receptor– ligand interactions
• Learnings from deeply characterized cannabinoid ligands, with examples of kinetic, biosensor, and target engagement assays

Speakers:

Arne Christian Rufer

Expert Scientist

Roche